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Tools & Approaches

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Tissue-specific RNAi

Depletion of tubulin specifically 
from Distal Tip Cell (DTC) 

A line ablation at the rachis (green) shows a rapid recoiling of the nearby membranes (magenta)

Laser ablation experiments

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CRISPR-Cas 9 mediated genome editing

CRISPR-Cas9 approach for endogenous labelling and site-specific mutations

FRAP analysis

Fluorescence-activated photobleaching(FRAP) of dendra-tagged laminin 

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A high-resolution image showing the enrichment of ARX-2 (green) at the front and NMY-2 (magenta) at the rear end of the DTC

High resolution imaging

Live imaging of EB2::mKate to visualize microtubule dynamics

Live imaging

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Quantitative image analysis

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Modeling (in collaboration)

Theoritical modeling predicting different gonad morphologies 

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